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Table 1 Time course of antigen challenge-induced changes in Penh value, and inhibitory effect of LTB4 via i.c.v. injection

From: Leukotriene B4, administered via intracerebroventricular injection, attenuates the antigen-induced asthmatic response in sensitized guinea pigs

Time

(min)

% Penh value change from baseline

 

NS-vehicle

OVA-vehicle

OVA-LTB4 30 ng

0

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

5

11.7 ± 9.5

179.5 ± 76.4##

40.2 ± 19.2 **

30

14.2 ± 8.3

61.0 ± 25.7#

18.8 ± 25.8 *

60

16.2 ± 17.0

28.6 ± 22.7

28.3 ± 31.6

120

8.8 ± 12.7

25.1 ± 34.6

18.2 ± 38.7

240

5.0 ± 15.2

22.2 ± 18.7

11.9 ± 22.4

1440

5.6 ± 29.5

12.6 ± 13.1

5.4 ± 30.0

  1. Data are expressed as mean ± S.E.M. for six animals per group.
  2. #P < 0.05, ##P < 0.01 significantly different from the NS-vehicle group;
  3. *P < 0.05, **P < 0.01 significantly different from the OVA-vehicle group.
  4. OVA, ovalbumin; NS, saline.
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Journal of Neuroinflammation

ISSN: 1742-2094