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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway

Figure 6

Double immunofluorescent staining for iNOS, IL-6, IL-1ß, TNF-α and actin in smooth muscle cells of the middle cerebral artery after MCAO. (A-C) Photographs demonstrating the localization of iNOS and actin immunostaining, and their co-localization in smooth muscle cells (yellow fluorescence in the merged picture). (D-F) IL-6 and actin immunostaining, and their co-localization in smooth muscle cells (white arrows). (G-I) IL-1ß and actin immunostaining, and their co-localization (yellow fluorescence in the merged picture) in smooth muscle cells. (J-L) TNF-α and actin immunostaining, and their co-localization in smooth muscle cells (yellow fluorescence in the merged picture). Enhanced expressions of iNOS, IL-1ß and TNF-α proteins are located in smooth muscle cells while IL-6 is located in both smooth muscle (white arrows) and endothelial cells (pink arrows). Scale bar, 50 μm.

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