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Table 2 Protein levels of iNOS, IL-6, IL-1ß and TNF-α in MCA after MCAO and treatment with U0126

From: Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway

Middle cerebral artery

 

Control

MCAO

MCAO + U0126-0 h

MCAO + U0126-6 h

MCAO + U0126-12 h

iNOS (%) ± s.e.m

100 ± 5

185 ± 16*

106 ± 9#

116 ± 9#

160 ± 9*

IL-6 (%) ± s.e.m

100 ± 6

177 ± 6**

113 ± 5#

110 ± 5#

137 ± 7

IL-1ß (%) ± s.e.m

100 ± 4

155 ± 4*

112 ± 8#

109 ± 4#

148 ± 16*

TNF-α ± s.e.m

100 ± 8.5

256 ± 24**

103 ± 8##

132 ± 12#

198 ± 7*

  1. Values are expressed as percentage of control and given as mean ± s.e.m, n = 5-6, * P < 0, 05, ** P < 0, 01, # P < 0, 05, ## P < 0, 01. * = significant difference between control groups and MCAO or control and treated at 12 hours, # = significant difference between MCAO and treatment groups (starting at 0 and 6 h).
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Journal of Neuroinflammation

ISSN: 1742-2094