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Table 2 Protein levels of iNOS, IL-6, IL-1ß and TNF-α in MCA after MCAO and treatment with U0126

From: Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway

Middle cerebral artery
  Control MCAO MCAO + U0126-0 h MCAO + U0126-6 h MCAO + U0126-12 h
iNOS (%) ± s.e.m 100 ± 5 185 ± 16* 106 ± 9# 116 ± 9# 160 ± 9*
IL-6 (%) ± s.e.m 100 ± 6 177 ± 6** 113 ± 5# 110 ± 5# 137 ± 7
IL-1ß (%) ± s.e.m 100 ± 4 155 ± 4* 112 ± 8# 109 ± 4# 148 ± 16*
TNF-α ± s.e.m 100 ± 8.5 256 ± 24** 103 ± 8## 132 ± 12# 198 ± 7*
  1. Values are expressed as percentage of control and given as mean ± s.e.m, n = 5-6, * P < 0, 05, ** P < 0, 01, # P < 0, 05, ## P < 0, 01. * = significant difference between control groups and MCAO or control and treated at 12 hours, # = significant difference between MCAO and treatment groups (starting at 0 and 6 h).