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Table 3 Protein levels of iNOS, IL-6, IL-1ß and TNF-α in microvessels after MCAO and treatment with U0126

From: Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway

Micro-vessels

 

Control

MCAO

MCAO + U0126-0 h

MCAO + U0126-6 h

MCAO + U0126-12 h

iNOS (%) ± s.e.m

100 ± 7.2

144 ± 1.0*

95 ± 10#

109 ± 3.01

112 ± 8.4

IL-6 (%) ± s.e.m

100 ± 8.6

134 ± 4.4*

106 ± 7.8#

101 ± 2.7#

119 ± 3.6

IL-1ß (%) ± s.e.m

100 ± 3.1

125 ± 4.9*

113 ± 5.5#

96 ± 2.4#

122 ± 14.2

TNF-α ± s.e.m

100 ± 7.1

205 ± 12*

117 ± 11#

117 ± 7.1#

149 ± 9*

  1. Values are expressed as percentage of control and given as mean ± s.e.m, n = 5-6,
  2. *and # P < 0, 05, * = significant difference between control groups and MCAO or control and treated at 12 hours, # = significant difference between MCAO and treatment groups (starting at 0 and 6 hours).
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Journal of Neuroinflammation

ISSN: 1742-2094