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Table 5 Protein levels of iNOS, IL-6, IL-1ß and TNF-α after MCAO and treatment with a combination of AT1/ETA receptor antagonists

From: Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway

  Middle cerebral artery Micro-vessels Brain tissue
  Control MCAO Treated Control MCAO Treated Control MCAO Treated
iNOS(%) ± s.e.m 100 ± 5.4 168 ± 7* 139 ± 7.7 100 ± 11.5 146 ± 10* 118 ± 13 100 ± 5 118 ± 9 106 ± 6
IL-6(%) ± s.e.m 100 ± 3 180 ± 13* 104 ± 3# 100 ± 4.9 146 ± 17* 103 ± 4 100 ± 8.9 109 ± 13 101 ± 12.2
IL-1ß(%) ± s.e.m 100 ± 5 146 ± 3* 117 ± 4.5 100 ± 5 117 ± 3.6 101 ± 3.8 100 ± 0.6 113 ± 4 102 ± 6.4
TNF-α ± s.e.m 100 ± 8 168 ± 8.7* 102 ± 12# 100 ± 5 117 ± 3.6 101 ± 3.8 100 ± 0.6 113 ± 4 102 ± 6.4
  1. Values are expressed as percentage of control and given as mean ± s.e.m, n = 3-4, #,* P < 0, 05, * significant difference between control groups and MCAO, # = significant difference between MCAO and treatment groups.