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Table 5 Protein levels of iNOS, IL-6, IL-1ß and TNF-α after MCAO and treatment with a combination of AT1/ETA receptor antagonists

From: Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway

 

Middle cerebral artery

Micro-vessels

Brain tissue

 

Control

MCAO

Treated

Control

MCAO

Treated

Control

MCAO

Treated

iNOS(%) ± s.e.m

100 ± 5.4

168 ± 7*

139 ± 7.7

100 ± 11.5

146 ± 10*

118 ± 13

100 ± 5

118 ± 9

106 ± 6

IL-6(%) ± s.e.m

100 ± 3

180 ± 13*

104 ± 3#

100 ± 4.9

146 ± 17*

103 ± 4

100 ± 8.9

109 ± 13

101 ± 12.2

IL-1ß(%) ± s.e.m

100 ± 5

146 ± 3*

117 ± 4.5

100 ± 5

117 ± 3.6

101 ± 3.8

100 ± 0.6

113 ± 4

102 ± 6.4

TNF-α ± s.e.m

100 ± 8

168 ± 8.7*

102 ± 12#

100 ± 5

117 ± 3.6

101 ± 3.8

100 ± 0.6

113 ± 4

102 ± 6.4

  1. Values are expressed as percentage of control and given as mean ± s.e.m, n = 3-4, #,* P < 0, 05, * significant difference between control groups and MCAO, # = significant difference between MCAO and treatment groups.