Figure 6
From: Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
Acute effects of celastrol on brain Aβ levels in 35 week-old Tg PS1/APPSw. Mice were treated for 4 days with an intraperitoneal injection of celastrol (1 mg/Kg of body weight) or the vehicle only (placebo). Multivariate analysis reveals a significant main effect of celastrol on brain soluble and insoluble Aβ levels (P < 0.05). Statistically significant differences were observed for soluble Aβ 1-42 values (P < 0.03) between vehicle and celastrol treated mice and for insoluble Aβ 1-40 (P < 0.001) and Aβ 1-42 values (P < 0.001) between vehicle and celastrol treated mice. (* P < 0.05; ** P < 0.001).