Table 1 Studies concerning immunosuppresive treatment of CAA encephalopathy
Author | n | Age | Pathology | Radiology | Therapy | Clinical improvement | Radiological improvement | Follow-up | Clinical features | Comments |
|---|---|---|---|---|---|---|---|---|---|---|
Ginsberg 1988 [10] | 1 | 73 | TGA | Confluent | Dx, Pn | Yes | Yes | >1 year | Gait disturbance | Â |
Mandybur 1992 [11] | 1 | 62 | TGA | Mass | CP, Pn | Yes | Yes | Death 8 months | Encephalopathy Focal neurology Hallucinations | Remarkable pathological improvement lesions post-mortem compared to initial biopsy |
Osumi 1995 [4] | 1 | 59 | ? | Mass | CS | No | ? | Death 5 months | Focal neurology Headaches Seizures | Â |
Silbert 1995 [12] | 1 | 74 | ? | Confluent | Dx | No | No | Death 6 weeks | Headache Seizures | Â |
Fountain 1996 [13] | 1 | 66 | TGA | Confluent | CP, Dx, Pn, | No | Partial | 20 months | Encephalopathy Headaches Seizures | Â |
Fountain 1996 [13] | 1 | 69 | TGA | Confluent | CP, Dx, Pn, | Partial | Partial | Death 6 months | Encephalopathy Headaches Seizures | Relapse |
Ortiz 1996 [14] | 1 | 68 | PVI | Mass | Dx, Pn | Yes | Yes | ? | Encephalopathy Gait disturbance Headaches | Â |
Masson 1998 [15] | 1 | 64 | PVI | Confluent | CP, Pn | Yes | No | 15 months | Encephalopathy Headaches | Â |
Fountain 1999 [16] | 1 | 71 | PVI, TGA | Confluent | CP | Yes | Yes | 22 months | Encephalopathy Gait disturbance Headaches | Relapse after stop CP |
Streichenberger 1999 [17] | 1 | 67 | TGA | Mass/Confluent | CS | Yes | Yes | Death 1 month | Headaches Encephalopathy | Â |
Hoshi 2000 [18] | 1 | 65 | - (after treatment) | Recurrent ICH | Pn | Yes | NA | 6 months | Focal neurology | Â |
Schwab 2003 [19] | 1 | 74 | PVI/TGA | Mass | Dx 1m, Pn | Yes | ? | 12 months | Encephalopathy Headaches Seizures | Â |
Schwab 2003 [19] | 1 | 70 | PVI//TGA | Mass | Pn, CP | Partial | Yes | 18 months | Encephalopathy Headaches Seizures | Â |
Oh 2004 [20] | 1 | 80 | PVI | Confluent | Dx, Pn | Yes | Yes | 8 months | Encephalopathy Focal Neurology Seizures | 1 patient with no therapy excluded |
Oh 2004 [20] | 1 | 77 | TGA | Confluent | Dx, Pn | Yes | Yes | 6 weeks | Encephalopathy Focal Neurology Seizures | 1 patient with no therapy excluded |
Safriel 2004 [5] | 1 | 49 | TGA | Mass | Dx, tap 6 weeks | Yes | Partial | 9 months | Seizures | Â |
Scolding 2005 [21] | 7 | 69* | TGA | Confluent | Pn, Dx, CP | 43% | ? | 58 months* | Encephalopathy Focal Neurology Headaches Seizures | 2 patients excluded because of mass resection as therapy |
Kinnecom 2007 [6] | 12 | 63.2 ± 10 | PVI | Confluent | CS, CP | 83% | 83% | 47 months* | Encephalopathy Headache Seizures | 25% relapse, 33% died |
McHugh 2007 [9] | 1 | 80 | PVI, TGA | Confluent | Pn | Yes | Yes | 24 months | Encephalopathy Focal Neurology Seizures | Â |
Machida 2008 [22] | 1 | 69 | PVI | Confluent | Dx, Pn | Yes | Yes | 12 months | Encephalopathy Focal neurology | Relapsing/remitting |
Salvarini 2008 [23] | 8 | 63 | TGA | Confluent | Pn, CP | 75% | 100% | 24 months* | Encephalopathy Focal Neurology Headaches | 25% relapse, both after discontinuation of treatment |