Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury

Table 4 Diagnostic accuracy of IL-6 for predicting subsequent elevations in ICP.

	Maximum ICP (mm Hg)	ELISA (pg/ml IL-6)	Classification	Actual
1	NA	undetectable	HV	HV
2	NA	undetectable	HV	HV
3	NA	undetectable	HV	HV
4	NA	2.01	HV	HV
5	NA	undetectable	HV	HV
6	NA	undetectable	HV	HV
7	NA	undetectable	HV	HV
8	20	76.31	ICP ≤ 20 mm Hg	ICP ≤ 20 mm Hg
9	16	148.58	ICP ≥ 25 mm Hg	ICP ≤ 20 mm Hg
10	20	54.66	ICP ≤ 20 mm Hg	ICP ≤ 20 mm Hg
11	19	63.53	ICP ≤ 20 mm Hg	ICP ≤ 20 mm Hg
12	20	251.51	ICP ≥ 25 mm Hg	ICP ≤ 20 mm Hg
13	16	57.48	ICP ≤ 20 mm Hg	ICP ≤ 20 mm Hg
14	19	93.45	ICP ≤ 20 mm Hg	ICP ≤ 20 mm Hg
15	20	94.6	ICP ≤ 20 mm Hg	ICP ≤ 20 mm Hg
16	30	188.17	ICP ≥ 25 mm Hg	ICP ≥ 25 mm Hg
17	28	573.01	ICP ≥ 25 mm Hg	ICP ≥ 25 mm Hg
18	26	152.78	ICP ≥ 25 mm Hg	ICP ≥ 25 mm Hg
19	31	>600	ICP ≥ 25 mm Hg	ICP ≥ 25 mm Hg
20	31	172.46	ICP ≥ 25 mm Hg	ICP ≥ 25 mm Hg
21	38	>600	ICP ≥ 25 mm Hg	ICP ≥ 25 mm Hg
22	30	43.52	ICP ≤ 20 mm Hg	ICP ≥ 25 mm Hg

Blinded samples, taken within the first 16 hr of injury (or from paired healthy volunteers), were analyzed for IL-6 content. HV: healthy volunteer

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