Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury

Table 5 Diagnostic accuracy of IL-6 for predicting subsequent elevations in ICP in patients with polytrauma.

	Maximum ICP (mm Hg)	IL-6 (pg/ml)	Classification	Actual
1	NA	undetectable	HV	HV
2	NA	2.06	HV	HV
3	NA	1.44	HV	HV
4	11	>600	ICP ≥ 25 mm Hg	ICP ≤ 20 mm Hg
5	16	140.28	ICP ≥ 25 mm Hg	ICP ≤ 20 mm Hg
6	20	50.01	ICP ≤ 20 mm Hg	ICP ≤ 20 mm Hg
7	20	518.70	ICP ≥ 25 mm Hg	ICP ≤ 20 mm Hg
8	12	75.00	ICP ≤ 20 mm Hg	ICP ≤ 20 mm Hg
9	34	85.21	ICP ≤ 20 mm Hg	ICP ≥ 25 mm Hg
10	32	342.89	ICP ≥ 25 mm Hg	ICP ≥ 25 mm Hg
11	28	189.76	ICP ≥ 25 mm Hg	ICP ≥ 25 mm Hg
12	38	30.91	ICP ≤ 20 mm Hg	ICP ≥ 25 mm Hg
13	34	236.90	ICP ≥ 25 mm Hg	ICP ≥ 25 mm Hg
14	26	466.18	ICP ≥ 25 mm Hg	ICP ≥ 25 mm Hg

Blinded samples taken within the first 16 hr of injury (or from paired healthy volunteers) were analyzed for IL-6 content. Serum IL-6 concentrations could be used to correctly identify only 6 of the 11 polytrauma patients tested (54%). HV: healthy volunteer.

ISSN: 1742-2094