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Table 1 Survey of seizure activity in mice after KA treatment.

From: Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice

 

Groups

Seizure Activity Variables

KO (n = 11)

WT (n = 10)

Tonic/clonic twitching without seizures

4/11

2/10

Seizures < 1 h

2/11

1/10

Seizures 1-3 h

1/11

2/10

Seizures > 3 h

1/11

2/10

Death due to seizures

3/11

3/10

Clinical scores (Medians with percentiles)

3 (1-6)

5 (1-6)

  1. Female IL-18 KO and WT mice, 18 to 19 months of age, were treated with KA at a dose of 25 mg/kg bodyweight intranasally. Mice were monitored continuously for 5 h to register the onset and extent of seizure activity. KA treatment resulted in various clinical symptoms in both IL-18 KO and WT mice. However, the severity of seizure did not differ significantly between the two groups.
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Journal of Neuroinflammation

ISSN: 1742-2094