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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype

Figure 3

Luteolin induces anti-oxidant, anti-inflammtory, and survival pathways. Real-time qRT-PCR validation of transcripts in BV-2 microglia stimulated with 50 μM luteolin, 50 ng/ml LPS, or 50 μM luteolin + 50 ng/ml LPS. Relative mRNA levels were quantified for (A) Sulfiredoxin 1 (Srxn1), (B) Biliverdin reductase b (Blvrb), (C) Heme oxigenase 1 (Hmox1), (D) Glutamate-cysteine ligase modifier subunit (Gclm), (E) Lysophosphatidylcholine acyltransferase 1 (Lpcat1), (F) Ring finger protein 145 (Rnf145), (G) Cd36 antigen (Cd36), (H) Kinase insert domain protein receptor (Kdr), and (I) Cd83 antigen (Cd83). Expression was normalized to the control gene Gusb and mRNA levels (+/- SEM) are graphed relative to mock-treated control cells. Results are calculated from three independent experiments performed in triplicate measurements. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 for luteolin vs. control and luteolin + LPS vs. LPS, respectively.

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