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Table 2 Differentially expressed transcripts after 24 h stimulation of BV-2 cells with 50 μM luteolin

From: Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype

Nr

ID

Symbol

Gene Name

FC*

Cov

UP-REGULATED

1

74315

Rnf145

Ring finger protein 145

2.87

11

2

76650

Srxn1

Sulfiredoxin 1 homolog

2.38

5

3

19252

Dusp1

Dual specificity phosphatase 1

2.35

10

4

12267

C3ar1

Complement component 3a receptor 1

2.30

22

5

12491

Cd36

CD36 antigen

2.28

10

6

12475

Cd14

CD14 antigen

2.25

10

7

233016

Blvrb

Biliverdin reductase B

2.22

9

8

15368

Hmox1

Heme oxygenase 1

2.17

10

9

210992

Lpcat1

Lysophosphatidylcholine acyltransferase 1

2.13

11

DOWN-REGULATED

1

13198

Ddit3

DNA-damage inducible transcript 3

-5.21

11

2

12862

Cox6a2

Cytochrome c oxidase, subunit VI a, polypeptide 2

-2.89

9

3

228775

Trib3

Tribbles homolog 3

-2.62

22

4

56312

Nupr1

Nuclear protein 1

-2.36

15

5

13011

Cst7

Cystatin F

-2.19

9

6

223920

Soat2

Sterol O-acyltransferase 2

-2.16

8

7

16149

Cd74

CD74 antigen

-2.10

8

8

17064

Cd93

CD93 antigen

-2.08

11

9

213002

Ifitm6

Interferon induced transmembrane protein 6

-2.06

8

  1. Significance analysis of triplicate microarrays was performed with a false discovery rate of 0.1% and a minimum probe coverage of 3. ID, Entrez Gene ID; FC: Fold change; Cov: probe coverage; * validated by Taqman realtime RT-PCR