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Table 3 Differentially expressed transcripts after 24 h stimulation with 50 μM luteolin + 50 ng/ml LPS versus 50 ng/ml LPS

From: Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype

Nr ID Symbol Gene Name FC* Cov
UP-REGULATED
1 74315 Rnf145 Ring finger protein 145 3.27 11
2 210992 Lpcat1 Lysophosphatidylcholine acyltransferase 1 2.55 11
3 12522 Cd83 CD83 antigen 2.51 11
4 14630 Gclm Glutamate-cysteine ligase, modifier subunit 2.46 10
5 16889 Lipa Lysosomal acid lipase A 2.31 6
6 56336 B4galt5 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 2.30 8
7 14950 H13 Histocompatibility 13 2.30 7
8 14104 Fasn Fatty acid synthase 2.28 4
9 12125 Bcl2l11 BCL2-like 11 2.16 14
10 16542 Kdr Kinase insert domain protein receptor 2.16 9
11 216345 Ccdc131 Coiled-coil domain containing 131 2.11 7
DOWN-REGULATED
1 66141 Ifitm3 Interferon induced transmembrane protein 3 -13.74 9
2 433470 AA467197 Expressed sequence AA467197, miR-147 -9.32 9
3 16819 Lcn2 Lipocalin 2 -6.87 10
4 14469 Gbp2 Guanylate binding protein 2 -6.41 16
5 14962 Cfb Complement factor B -5.94 8
6 13198 Ddit3 DNA-damage inducible transcript 3 -5.58 11
7 16181 Il1rn Interleukin 1 receptor antagonist -5.28 33
8 55932 Gbp3 Guanylate binding protein 3 -4.72 10
9 56312 Nupr1 Nuclear protein 1 -4.35 15
10 75345 Slamf7 SLAM family member 7 -4.14 9
11 20210 Saa3 Serum amyloid A 3 -3.78 7
12 17386 Mmp13 Matrix metallopeptidase 13 -3.63 11
13 15439 Hp Haptoglobin -3.56 11
14 17167 Marco Macrophage receptor with collagenous structure -3.34 8
15 12266 C3 Complement component 3 -3.29 6
16 12870 Cp Ceruloplasmin -3.05 5
17 13011 Cst7 Cystatin F -3.03 9
18 23882 Gadd45g Growth arrest and DNA-damage-inducible 45 gamma -2.95 11
19 242341 Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 -2.81 13
20 68774 Ms4a6d Membrane-spanning 4-domains, subfamily A, member 6D -2.75 19
21 83673 Snhg1 Small nucleolar RNA host gene 1 -2.75 24
22 12494 Cd38 CD38 antigen -2.73 6
23 19655 Rbmx RNA binding motif protein, X chromosome -2.73 11
24 56405 Dusp14 Dual specificity phosphatase 14 -2.68 10
25 213002 Ifitm6 Interferon induced transmembrane protein 6 -2.57 8
26 12517 Cd72 CD72 antigen -2.55 9
27 14129 Fcgr1 Fc receptor, IgG, high affinity I -2.55 11
28 14130 Fcgr2b Fc receptor, IgG, low affinity IIb -2.48 27
29 231532 Arhgap24 Rho GTPase activating protein 24 -2.46 8
30 29818 Hspb7 Heat shock protein family, member 7 (cardiovascular) -2.45 5
31 17476 Mpeg1 Macrophage expressed gene 1 -2.43 6
32 66222 Serpinb1a Serine peptidase inhibitor, clade B, member 1a -2.41 10
33 78771 Mctp1 Multiple C2 domains, transmembrane 1 -2.39 8
34 20568 Slpi Secretory leukocyte peptidase inhibitor -2.39 9
35 12507 Cd5 CD5 antigen -2.35 9
36 50778 Rgs1 Regulator of G-protein signaling 1 -2.35 11
37 21897 Tlr1 Toll-like receptor 1 -2.20 5
38 16149 Cd74 CD74 antigen -2.17 5
39 73167 Arhgap8 Rho GTPase activating protein 8 -2.13 8
40 15064 Mr1 Major histocompatibility complex, class I-related -2.06 7
41 347722 Centg2 Centaurin, gamma 2 -2.04 11
42 98365 Slamf9 SLAM family member 9 -2.04 8
43 72999 Insig2 Insulin induced gene 2 -2.00 8
  1. Significance analysis of triplicate microarrays was performed with a false discovery rate of 0.1% and a minimum probe coverage of 3. ID, Entrez Gene ID; FC: Fold change; Cov: probe coverage; * validated by Taqman realtime RT-PCR