Figure 1
From: In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases
CSF CHI3L1 levels in neurodegenerative diseases and stroke. CSF samples from MS, AD, ALS, stroke and control patients were analyzed for CHI3L1 using the CHI3L1 ELISA kit. The Mann-Whitney test was used to evaluate group differences (*P < 0.05, **P < 0.001, ***P < 0.0001). CSF YKL-40 levels in MS patients were significantly elevated compared to young, age-matched controls (A). While all neurodegenerative diseases and stroke show difference from young controls, AD, ALS and stroke patients do not show significant differences when compared to older age-matched controls (B).