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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2

Figure 4

Decreased neurotoxicity from HSV-infected TLR2-/- microglia compared to wild-type cells. Purified murine microglia from wild-type and TLR2-/- mice were infected with HSV-1 (2 MOI). Cells were harvested at 90 min p.i. and transferred, at the designated microglia: neuron ratios, onto β-actin luciferase mixed neural cultures. Luciferin emission was measured 48 h after microglial cell transfer. Data were normalized to untouched β-actin luciferase mixed neural cultures and presented as the % of control. Data are presented as mean pg/mL of 8-isoprostane ± SD and are a representative of three separate experiments. *** p < 0.001.

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