Figure 5
From: Key role for spinal dorsal horn microglial kinin B1receptor in early diabetic pain neuropathy
Effect of microglia inhibitors administered 3 h earlier on tail-flick reaction time (MPE %) in control and 4-day STZ-diabetic rats. Shown are the maximal responses measured 1 min after intrathecal injection of either aCSF, 9.6 nmol des-Arg9-BK or 6.6 nmol SP. Data are the mean ± S.E.M. of 5 rats in each group. Within groups, statistical comparison to aCSF is indicated by ††P < 0.01, while statistical comparison to the same agonist in the control group (*) or in STZ + vehicle (+) is indicated by * + P < 0.05; ++ ††P < 0.01; ***P < 0.001.