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Table 2 Gene expression of various markers in thoracic spinal cord of STZ-diabetic rats

From: Key role for spinal dorsal horn microglial kinin B1receptor in early diabetic pain neuropathy

 

gene mRNA/18S mRNA (fold change)

 

B1R

TRPV1

IL-1β

TNF-α

Control

1.0 ± 0.4

1.0 ± 0.1

1.0 ± 0.6

1.0 ± 0.6

STZ

27.3 ± 8.7 *

3.1 ± 0.4 *

77.9 ± 19.6 *

6.0 ± 2.1 **

STZ + Fluorocitrate

2.7 ± 1.1

2.3 ± 0.3 +

10.1 ± 7.9

0.9 ± 0.4 +

STZ + Minocycline

3.0 ± 1.3

2.6 ± 0.2 +

8.9 ± 4.2

2.1 ± 0.7 +

  1. Effect of a 3 h pre-treatment with fluorocitrate (1 nmol, i.t.) or minocycline (10 mg/kg, i.p.) on gene expression of inflammatory markers in thoracic spinal cord of STZ-diabetic rats. Data represent the mean ± S.E.M. of 5-6 rats in each group. Statistical comparison to control (*) and STZ-diabetic rats without microglia inhibitors (+) is indicated by * + P < 0.05; **P < 0.01.
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Journal of Neuroinflammation

ISSN: 1742-2094