Table 3 Effect of spinal cord B1R stimulation on tactile allodynia in STZ-diabetic rats
From: Key role for spinal dorsal horn microglial kinin B1receptor in early diabetic pain neuropathy
Tactile allodynia (g) | ||||||
|---|---|---|---|---|---|---|
0 min | 5 min | 10 min | 15 min | 30 min | 60 min | |
Control rats | ||||||
Vehicle | 9.7 ± 0.3 | 9.7 ± 0.3 | 9.3 ± 0.7 | 9.7 ± 0.3 | 9.7 ± 0.3 | 9.7 ± 0.3 |
DABK (9.6 nmol, i.t.) | 9.7 ± 0.3 | 9.7 ± 0.3 | 9.3 ± 0.7 | 9.7 ± 0.3 | 9.7 ± 0.3 | 9.7 ± 0.3 |
SSR240612 (10 μg, i.t.) + DABK | 10.7 ± 0.3 | 9.7 ± 0.3 | 9.3 ± 0.7 | 9.7 ± 0.3 | 9.7 ± 0.3 | 9.7 ± 1.3 |
FLU (1 nmol, i.t.) + DABK | 9.7 ± 0.3 | 9.7 ± 0.3 | 9.3 ± 0.7 | 9.7 ± 0.3 | 9.7 ± 0.3 | 9.7 ± 0.3 |
Mino (10 mg/kg, i.p.) + DABK | 9.7 ± 0.3 | 9.7 ± 0.3 | 9.3 ± 0.7 | 9.7 ± 0.3 | 9.7 ± 0.3 | 9.7 ± 0.3 |
Tactile allodynia (g) | ||||||
0 min | 5 min | 10 min | 15 min | 30 min | 60 min | |
STZ-treated rats | ||||||
Vehicle | 6.3 ± 0.3*** | 6.0 ± 0.5*** | 6.3 ± 0.3*** | 6.3 ± 0.3*** | 6.3 ± 0.3*** | 6.0 ± 0.5*** |
DABK (9.6 nmol, i.t.) | 6.0 ± 0.5*** | 5.3 ± 0.4*** | 4.3 ± 0.3++ *** | 5.3 ± 0.4*** | 6.0 ± 0.0*** | 5.7 ± 0.3*** |
SSR240612 (10 μg, i.t.) + DABK | 9.3 ± 0.3+++ | 9.3 ± 0.0+++ | 9.3 ± 0.0+++ | 9.3 ± 0.3+++ | 9.7 ± 0.3+++ | 9.3 ± 0.0+++ |
FLU (1 nmol, i.t.) + DABK | 9.7 ± 0.3+++ | 9.7 ± 0.3+++ | 9.7 ± 0.3+++ | 9.7 ± 0.3+++ | 9.3 ± 0.4+++ | 9.3 ± 0.4+++ |
Mino (10 mg/kg, i.p.) + DABK | 9.7 ± 0.3+++ | 9.0 ± 0.4+++ | 9.3 ± 0.4+++ | 9.3 ± 0.4+++ | 8.7 ± 0.4+++ | 9.3 ± 0.4+++ |