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Table 1 Donor splenic lymphocyte population *Splenocyte population (%)

From: Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

Donor

B220+

CD3+

F4/80+

mice

 

CD4+

CD8+

 

wt

47.7

22.2

15.2

8.25

MPS IIIB

55.5

14.6

14.5

14.1

  1. *Splenic lymphocytes isolated from age-matched (10-12-week-old) male MPS IIIB or wt mice were pooled and stimulated with ConA (1 μg/ml in RPMI growth media) for 48 hrs. Data represent the average of two independent experiments (n = 8 donors/group/experiment).