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Table 3 Effect of adoptive transfer of MPS IIIB lymphocytes on the expression of immune-associated genes in the brain of recipient mice

From: Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

Gene symbol

Gene name

GenBank access #

#2-ΔΔCt (fold of increase)

IFN-γ

Interferon gamma

NM_008337

17.8*

CD68

CD68 antigen

NM_009853

5.2*

GFAP

Glial fibrillary acidic protein

NM_010277

4.1*

IL4

Interleukin 4

NM_021283

2.8*

IL5

Interleukin 5

NM_010558

1.7*

IL6

Interleukin 6

NM_031168

1.3

IL17

Interleukin 17

NM_010552

2.1*

IL2

Interleukin 2

NM_008366

1.9*

TNF-α

Tumor necrosis factor alpha

NM_013693

1.9*

CD45

Protein tyrosine phosphatase receptor type C

NM_011210

1.7*

Ifi30

Interferon gamma inducible protein 30

NM_023065

1.8*

IFN-α

Interferon alpha

NM_008334

1.6*

CD3e

CD3 antigen, epsilon polypeptide

NM_007648

1.3*

CD4

CD4 antigen

NM_013488

1.4*

CD8a

CD8 antigen, alpha chain

NM_001081110

1.2

IL10

Interleukin 10

NM_010548

1.0

  1. #Real-time qRT-PCR data were analyzed by means of the comparative threshold (CT) method using mouse GAPDH as internal control and expressed as 2-ΔΔCt. These changes reflect relative increases in gene expression in the brain of mice receiving MPS IIIB lymphocytes (n = 4) as compared to wild-type lymphocytes-treated mice (n = 4). *P < 0.05 (ΔΔCt of MPS IIIB lymphocytes-treated mouse brains vs. wild-type lymphocytes-treated mouse brains).