IL-1β significantly increases in rat brain after GD-induced SE. Though much less robust than IL-1α, IL-1β concentrations significantly increase in the piriform cortex twelve hours following GD-induced seizure activity (solid gray line). Concentrations of IL-1β also significantly increase in the thalamus (open gray line) though not in the hippocampus (solid black line). Also unlike IL-1α, IL-1β concentrations in naives were high and variable compared to experimental data. * p < 0.05 versus vehicle control in piriform cortex, $$ p < 0.01 versus vehicle control in thalamus.