Neurons in the ischemic core of the cPLA
α-/- mouse are protected from injury. A: Neuronal swelling was measured by threshold densitometry in brains from cPLA2α+/+ and cPLA2α-/- mice after 2-hour MCAO, 2-hour MCAO and 2 hours of reperfusion, or sham surgery; n = 3 mice/condition; * P < 0.01, unpaired t-test comparing cPLA2α+/+ to -/- at same condition. B: Nissl staining of cPLA2α+/+ and cPLA2α-/- brains after 2-hour MCAO and 6 hours of reperfusion. Vacuolated neurons (arrows) and nuclear condensation (arrowheads) are seen in the ischemic core of cPLA2α+/+ mice. Ipsi, ipsilateral; Contra, contralateral; C, ischemic core; P, penumbra.