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Table 1 cPLA2α+/+ and -/- neuron size after MCAO, reperfusion or sham surgery

From: Cytosolic phospholipase A2alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice

  cPLA2α+/+ Neuron Area (arbitrary units) cPLA2α-/- Neuron Area (arbitrary units)
  Ipsilateral Contralateral Ipsilateral Contralateral
  Core Penumbra Core Penumbra Core Penumbra Core Penumbra
0 h Reperfuse 1.12 ± 0.21* 1.22 ± 0.30 * 0.55 ± 0.12 0.61 ± 0.15 0.68 ± 0.19 0.72 ± 0.12 0.46 ± 0.12 0.49 ± 0.08
2 h Reperfuse 0.91 ± 0.25 1.08 ± 0.28 * 0.62 ± 0.09 0.67 ± 0.18 0.83 ± 0.26 0.89 ± 0.21 0.53 ± 0.2 0.62 ± 0.11
Sham 0.52 ± 0.09 0.60 ± 0.09 0.47 ± 0.13 0.63 ± 0.11 0.40 ± 0.13 0.43 ± 0.09 0.44 ± 0.12 0.45 ± 0.09
  1. Relative neuron size was determined in fluorescent Nissl-stained brain sections by threshold densitometry. Sections from the ipsilateral and contralateral hemispheres were matched for position in mice that were subjected to 2 hours MCAO, MCAO and 2 hours reperfusion or sham surgery. The data are an index of the average number of pixels in a neuron for each condition. * P < 0.01 for +/+ as compared to -/- of the same condition.