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Table 1 cPLA2α+/+ and -/- neuron size after MCAO, reperfusion or sham surgery

From: Cytosolic phospholipase A2alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice

 

cPLA2α+/+ Neuron Area (arbitrary units)

cPLA2α-/- Neuron Area (arbitrary units)

 

Ipsilateral

Contralateral

Ipsilateral

Contralateral

 

Core

Penumbra

Core

Penumbra

Core

Penumbra

Core

Penumbra

0 h Reperfuse

1.12 ± 0.21*

1.22 ± 0.30 *

0.55 ± 0.12

0.61 ± 0.15

0.68 ± 0.19

0.72 ± 0.12

0.46 ± 0.12

0.49 ± 0.08

2 h Reperfuse

0.91 ± 0.25

1.08 ± 0.28 *

0.62 ± 0.09

0.67 ± 0.18

0.83 ± 0.26

0.89 ± 0.21

0.53 ± 0.2

0.62 ± 0.11

Sham

0.52 ± 0.09

0.60 ± 0.09

0.47 ± 0.13

0.63 ± 0.11

0.40 ± 0.13

0.43 ± 0.09

0.44 ± 0.12

0.45 ± 0.09

  1. Relative neuron size was determined in fluorescent Nissl-stained brain sections by threshold densitometry. Sections from the ipsilateral and contralateral hemispheres were matched for position in mice that were subjected to 2 hours MCAO, MCAO and 2 hours reperfusion or sham surgery. The data are an index of the average number of pixels in a neuron for each condition. * P < 0.01 for +/+ as compared to -/- of the same condition.