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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

Figure 1

LPS administered via the i.c.v . route induces both sickness and depressive-like behavior. Mice were injected i.c.v. with either saline or LPS (100 ng). (A) Social behavior was measured during a 5 min period at 0, 4, 8 and 24 h following LPS injection. (B) Duration of immobility was quantified during a 6 min forced swim test that was recorded 24 h following administration of LPS. Data represent mean ± SEM (n = 4-6 mice/group). * p < 0.05, ** p < 0.01 compared to saline.

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Journal of Neuroinflammation

ISSN: 1742-2094