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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

Figure 2

Central administration of LPS induces (A) IDO, (B) TNFα, (C) IL-6 and (D) iNOS mRNA upregulation in the hippocampus. Mice were injected i.c.v. with either saline or LPS (100 ng) and the hippocampi were collected 6 h later. Steady-state expression of mRNA transcripts was measured by real-time RT-PCR. Average Ct values for LPS-treated mice were as follows: IDO = 33.0 ± 0.4; TNFα = 23.3 ± 0.4; IL-6 = 24.2 ± 0.4; iNOS = 28.0 ± 0.3. Data represent mean ± SEM (n = 4-5 mice/group). * p < 0.05, ** p < 0.01 compared to saline.

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