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Table 3 Admission levels of inflammatory and coagulation biomarkers in patients according to dichotomized Glasgow Outcome Scores (GOS) and resuscitation treatment group.

From: Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patients

Marker

 

GOS Score

 
 

HSD

NS

 

Poor (1-3)

Good (4-5)

Poor (1-3)

Good (4-5)

CD62L, MFI §

48.5 ± 4.6b

33.7 ± 4.7a,b

58.5 ± 5.9

45.3 ± 4.4a

CD11b, MFI §

443.3 ± 58.7b

377.4 ± 28.3a,b

539.3 ± 91.8

505.9 ± 51.4

CD66b, MFI §

124.4 ± 28.4

74.6 ± 7.2a,b

135.1 ± 17.9

118.0 ± 8.3a

sICAM-1, pg/mL

228.3 ± 28.3b

211.1 ± 19.1b

254.4 ± 13.5

238.4 ± 29.0

sVCAM-1, pg/mL

713.8 ± 67.3b

574.2 ± 70.0a,b

757.0 ± 60.3

741.1 ± 54.8

sE-Selectin, pg/mL

33.9 ± 3.0b

31.1 ± 4.0b

45.2 ± 3.8

42.5 ± 4.6

sL-Selectin, pg/mL

849.2 ± 64.7b

875.2 ± 87.3b

770.3 ± 69.4

870.1 ± 60.0a

TNF-α, pg/mL

7.2 ± 2.4b

4.9 ± 1.7a,b

14.8 ± 1.4

6.9 ± 1.3a

IL-10, pg/mL

19.6 ± 6.3b

12.9 ± 2.2a,b

30.3 ± 4.9

26.4 ± 4.8a

TF, pg/mL

42.0 ± 4.3b

39.5 ± 12.6b

78.7 ± 10.5

65.8 ± 15.9a

TM, ng/mL

4.0 ± 1.1b

3.6 ± 1.3b

2.1 ± 1.3

2.8 ± 1.1

D-D, μg/mL

6.8 ± 2.3b

6.4 ± 1.2b

12.1 ± 2.1

7.6 ± 1.9a

  1. Data are expressed as mean ± standard error mean (SEM) for each marker.
  2. § MFI, mean fluorescence intensity of surface antigen expression by neutrophils.
  3. Abbreviations: NS, normal saline; HSD, hypertonic saline-dextran; GOS, Glasgow Outcome Scale score.
  4. aP < 0.05 vs GOS 1-3; bP < 0.05 vs NS treated patients, by unpaired t-test.