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Table 3 Admission levels of inflammatory and coagulation biomarkers in patients according to dichotomized Glasgow Outcome Scores (GOS) and resuscitation treatment group.

From: Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patients

Marker   GOS Score  
  HSD NS
  Poor (1-3) Good (4-5) Poor (1-3) Good (4-5)
CD62L, MFI § 48.5 ± 4.6b 33.7 ± 4.7a,b 58.5 ± 5.9 45.3 ± 4.4a
CD11b, MFI § 443.3 ± 58.7b 377.4 ± 28.3a,b 539.3 ± 91.8 505.9 ± 51.4
CD66b, MFI § 124.4 ± 28.4 74.6 ± 7.2a,b 135.1 ± 17.9 118.0 ± 8.3a
sICAM-1, pg/mL 228.3 ± 28.3b 211.1 ± 19.1b 254.4 ± 13.5 238.4 ± 29.0
sVCAM-1, pg/mL 713.8 ± 67.3b 574.2 ± 70.0a,b 757.0 ± 60.3 741.1 ± 54.8
sE-Selectin, pg/mL 33.9 ± 3.0b 31.1 ± 4.0b 45.2 ± 3.8 42.5 ± 4.6
sL-Selectin, pg/mL 849.2 ± 64.7b 875.2 ± 87.3b 770.3 ± 69.4 870.1 ± 60.0a
TNF-α, pg/mL 7.2 ± 2.4b 4.9 ± 1.7a,b 14.8 ± 1.4 6.9 ± 1.3a
IL-10, pg/mL 19.6 ± 6.3b 12.9 ± 2.2a,b 30.3 ± 4.9 26.4 ± 4.8a
TF, pg/mL 42.0 ± 4.3b 39.5 ± 12.6b 78.7 ± 10.5 65.8 ± 15.9a
TM, ng/mL 4.0 ± 1.1b 3.6 ± 1.3b 2.1 ± 1.3 2.8 ± 1.1
D-D, μg/mL 6.8 ± 2.3b 6.4 ± 1.2b 12.1 ± 2.1 7.6 ± 1.9a
  1. Data are expressed as mean ± standard error mean (SEM) for each marker.
  2. § MFI, mean fluorescence intensity of surface antigen expression by neutrophils.
  3. Abbreviations: NS, normal saline; HSD, hypertonic saline-dextran; GOS, Glasgow Outcome Scale score.
  4. aP < 0.05 vs GOS 1-3; bP < 0.05 vs NS treated patients, by unpaired t-test.
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Journal of Neuroinflammation

ISSN: 1742-2094