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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Hemin inhibits NO production by IL-1β-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation

Figure 1

Inhibition of iNOS expression and NO production in human astrocytes. Human astrocyte cultures were treated with hemin (10 and 20 μM) for 24 h prior to IL-1β (10 ng/ml) exposure for A) 4 h or 24 h for RNA extraction to measure iNOS mRNA expression or B) 72 h to measure NO concentration in culture supernatants. Data presented in A) are representative of 3 separate experiments and in B) are mean ± SE of triplicates from different brain tissue specimens. ** p < 0.01 vs. untreated control (C); ††p < 0.01 vs. IL-1β alone.

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