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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Hemin inhibits NO production by IL-1β-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation

Figure 3

Blockade of hemin-induced NO inhibition. Human astrocyte cultures were pretreated with SnPP (10 μM) for 3 h prior to hemin (10 and 20 μM) treatment for 24 h followed by IL-1β (10 ng/ml) exposure for 72 h before measuring NO concentration in culture supernatants. Data presented are mean ± SE of triplicates from 3 separate experiments using different brain tissue specimens. ** p < 0.01 vs. IL-1β alone; ††p < 0.01 vs. corresponding hemin+IL-1β.

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