Inhibition of nuclear factor-κB by 6-O-acetyl shanzhiside methyl ester protects brain against injury in a rat model of ischemia and reperfusion

Table 1 Effects of ND02 on survival, neurological scores, infarct volume, and brain water content in ischemia-reperfused rats: a dose-response study

Group	Survival (# rats)	Neurological scores (median/range)	Infarct volume (%)	Brain water content (%)
Sham	15/15	---	---	76.8 ± 0.5
Vehicle-treated	9/15	4/2	27.4 ± 6.3	78.8 ± 0.4
ND02 1.6 mg/kg	9/15	4/3	24.8 ± 4.2	78.6 ± 0.4
ND02 4 mg/kg	10/15	4/3	23.3 ± 4.8	78.4 ± 0.5
ND02 10 mg/kg	10/15	3/3*	19.7 ± 6.2*	78.2 ± 0.7*
ND02 25 mg/kg	11/15	3/4**	17.4 ± 4.8**	77.9 ± 0.5**
ND02 62.5 mg/kg	12/15	2/4**	12.8 ± 3.5**	77.8 ± 0.5**

Data are means ± SD, with n = 15 for each group. ND02, at doses ranging from 1.6 to 62.5 mg/kg, was administered intravenously 30 min after cerebral I/R. ^#P < 0.01 vs. sham group; *P < 0.05, **P < 0.01 vs vehicle-treated group. Cerebral infarct volume and brain water content between groups were compared using one-way ANOVA followed by Dunnett's test. Neurological scores between groups were compared using a nonparametric test.

ISSN: 1742-2094