Inhibition of nuclear factor-κB by 6-O-acetyl shanzhiside methyl ester protects brain against injury in a rat model of ischemia and reperfusion

Table 2 Effects of ND02 on survival, neurological scores, infarct volume, and brain water content in ischemia-reperfused rats: a therapeutic time-window study

Group		Survival (# rats)	Neurological scores (median/range)	Infacrt volume (%)	Brain water content (%)
Sham		15/15	---	---	76.7 ± 0.5
Vehicle-treated		10/15	4/2	26.1 ± 4.5	78.9 ± 0.4
	1 h	13/15	2/3**	15.8 ± 3.9**	77.9 ± 0.6**
	3 h	12/15	3/4*	18.6 ± 5.1**	78.1 ± 0.4**
ND02 25	5 h	11/15	3/3*	21.8 ± 4.1*	78.4 ± 0.5*
	7 h	10/15	3/3	22.9 ± 6.6	78.6 ± 0.4

Data are means ± SD, with n = 15 for each group. ND02 was administered at a dose of 25 mg/kg at 1 h, 3 h, 5 h and 7 h after cerebral I/R. Data are means ± SD. ^#P < 0.01 vs. sham group; *P < 0.05, **P < 0.01 vs vehicle-treated group. Cerebral infarct volumes of different groups were compared using one-way ANOVA followed by Dunnett's test. Neurological deficit scores between groups were compared using a nonparametric test.

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