Figure 5
From: LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
Increased phosphor-tau staining after LPS. Immunohistochemical staining of tau phosphorylated at Ser199/202 in anterior cortex (A-D), hippocampus (CA1; F-I), and entorhinal cortex (ECX; K-N) after vehicle (A, B, F, G, K, L) or LPS (C, D, H, I, M, N) administration in rTg4510 (B, D, G, I, L, N) or nontransgenic control mice (A, C, F, H, K, M). Panels E, J and O present mean ± S.E.M of % Area for immunostaining. Phospho-Tau Ser199/202 staining increased in both anterior cortex and ECX of rTg4510 mice treated with LPS compared to vehicle- treated mice. No staining was detected in nontransgenic littermates. Statistical analysis was performed using 2-way ANOVA followed by Fisher's PLSD multiple comparison test. (*p < 0.05), n = 6-8. Scale bar represents 20 μm.