Figure 7

Argyrophilic tau inclusions did not increase after LPS. Argyrophilic tau was identified with the Gallyas silver stain in cortex (A-D), hippocampus (CA1; F-I), and entorhinal cortex (ECX; K-N) in nontransgenic (A, C, F, H, K, M) and rTg4510 (B, D, G, I, L, N) mice after injection with LPS (B, D, G, I, L, N) or vehicle (A, C, F, H, K, M). Panels E, J, and O present mean ± S.E.M of % Area for Gallyas silver positive staining. There were no significant changes in silver positive neurons in any brain region of mice treated with LPS compared to vehicle-treated mice. Statistical analysis was performed using 2-way ANOVA followed by Fisher's PLSD multiple comparison test (*p < 0.05), n = 6-8. Scale bar represents 20 μm.