Figure 8From: LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 miceTotal tau was not increased by LPS. Immunohistochemical staining using an antibody that recognizes multiple isoforms of tau regardless of phosphorylation is presented in anterior cortex (CX; A, B, G, H), hippocampus (CA1; C, D, I, J), and entorhinal cortex (ECX; E, F, K, L) after vehicle (A, C, E, G, I, K) or LPS (B, D, G, H, J, L) administration in nontransgenic (A-F) or rTg4510 (G-L) mice. No immunoreactive staining was observed for total tau in nontransgenic littermates. Mean ± S.E.M (n = 6-8) of % Area for total tau positive staining (M) reveals that there were no significant changes in tau positive staining in the CX, CA1, or ECX of mice treated with LPS compared to vehicle-treated mice. Statistical analysis was performed using 2-way ANOVA followed by Fisher's PLSD multiple comparison test. Scale bar represents 20 μm.Back to article page