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Table 1 LPS-Induced Microglia Activation on Contralateral Hemisphere

From: LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

  

nTg

rTg4510

CD45

Region

Vehicle

LPS

Vehicle

LPS

 

CX

0.008 ± 0.003

0.397 ± 0.162

0.161 ± 0.110

0.778 ± 0.270 a

 

CA1

0.027 ± 0.015

0.410 ± 0.100

0.250 ± 0.151

0.489 ± 0.154 a

 

CA3

0.061 ± 0.020

2.325 ± 0.431

0.112 ± 0.024

1.310 ± 0.527 a

 

ECX

0.530 ± 0.093

0.920 ± 0.182

0.541 ± 0.118

0.875 ± 0.409

YM1

Region

Vehicle

LPS

Vehicle

LPS

 

CX

0.001 ± 0.001

0.024 ± 0.005

0.001 ± 0.001

0.018 ± 0.006 a

 

CA1

0.003 ± 0.002

0.025 ± 0.007

0.002 ± 0.001

0.100 ± 0.036 a,b

 

CA3

0.001 ± 0.001

0.049 ± 0.008

0.004 ± 0.002

0.154 ± 0.049 a,b

 

ECX

0.005 ± 0.002

0.080 ± 0.020

0.001 ± 0.001

0.586 ± 0.189 a,b

Arg-1

Region

Vehicle

LPS

Vehicle

LPS

 

CX

0.008 ± 0.001

0.012 ± 0.005

0.005 ± 0.001

0.008 ± 0.002

 

CA1

0.014 ± 0.002

0.020 ± 0.007

0.008 ± 0.003

0.013 ± 0.003

 

CA3

0.017 ± 0.002

0.044 ± 0.024

0.007 ± 0.002

0.047 ± 0.023

 

ECX

0.021 ± 0.004

0.039 ± 0.014

0.016 ± 0.005

0.030 ± 0.010

  1. For each marker, 2-way ANOVA follwed by Fisher's LSD Analysis for genotype and treatment were performed. ap < 0.05, Vehicle v.s LPS; bp < 0.05, nTg v.s rTg4510 mice. CD45; microglial activation marker, YM1; microglial alternative activation marker, Arginase-1; alternative activation marker. CX; anterior cortex, CA1 and CA3; hippocampus CA1 and CA3 respectfully, ECX; entorhinal cortex. n = 5-8.