Figure 3

Plasma Aβ is decreased in 22 month old PFA1 treated female mice and increased in 22 month old PFA1 treated male mice. A. Aβ1-40 levels were measured from plasma collected from vehicle and PFA1 treated female mice before and after 4 weeks of treatment. There was no significant change in plasma Aβ1-40 levels following treatment in vehicle treated animals. There was a significant 44% decrease (p < 0.01) in plasma Aβ1-40 levels following PFA1 treatment. B. Aβ1-42 levels were measured from plasma collected from vehicle and PFA1 treated female mice before and after treatment. There were no significant changes to Aβ1-42 in either the vehicle or PFA1 group following treatment. C. Aβ1-40 levels were measured from plasma collected from vehicle and PFA1 treated male mice before and after 4 weeks of treatment. There was no significant change in plasma Aβ1-40 levels following treatment in vehicle treated male mice. There was a significant 128% increase (p < 0.05) in Aβ1-40 levels following treatment in the PFA1 treated male mice. D. Aβ1-42 levels were measured from plasma collected from male mice before and after vehicle or PFA1 treatment. There were no significant changes to Aβ1-42 levels following treatment in either vehicle or PFA1 group.