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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

Figure 5

TGFβ and SDF1 are negatively correlated with brain Aβ, while TNFα and MCP-1 are positively correlated in 22 month old mice. A. Correlational analyses were performed between inflammatory cytokines and soluble (DEA) brain Aβ1-40 levels in female mice. TGFβ and SDF1 were significantly negatively correlated with Aβ1-40 levels (R2 = 0.4633, p < 0.01; R2 = 0.6421, p < 0.001, respectively). Other cytokines were not significantly correlated with soluble Aβ1-40. B. TGFβ and SDF1 were also significantly correlated with soluble Aβ1-42 levels (R2 = 0.4371, p < 0.01; R2 = 0.5489, p < 0.01, respectively). Other cytokines were not significantly correlated with soluble Aβ1-42. C. Correlational analyses were performed between inflammatory cytokines and total Aβ1-40 levels in male mice. TNFα was significantly correlated with total (FA) Aβ1-40 levels (R2 = 0.3851, p < 0.05). Other cytokines were not significantly correlated with total Aβ1-40. D. Data from female and male mice were combined and correlational analyses performed. TNFα and MCP-1 were significantly correlated with soluble Aβ1-40 levels (R2 = 0.1871, p < 0.01; R2 = 0.2466, p < 0.01, respectively). Other cytokines were not significantly correlated with soluble Aβ1-40. E. MCP-1 was significantly correlated with total Aβ1-40 levels in females and males (R2 = 0.1780, p < 0.05). F. TNFα and MCP-1 were significantly correlated with soluble Aβ1-42 levels in females and males (R2 = 0.2018, p < 0.05).

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