Figure 6

PFA1 treated 22 month old male, but not female, mice show a decreased trend in phospho-tau. A. Brain homogenates from PFA1-treated 22 month old female mice were Western blotted for phospho-tau (AT8, AT180) or total tau. PFA1-treated female mice did not show any significant differences in phospho-tau by either AT8 or AT180 normalized to total tau levels. B. Brain homogenates from PFA1-treated 22 month old male mice were Western blotted for phospho-tau or total tau. PFA1-treated male mice showed a trend towards decreased phospho-tau by AT180 normalized to total tau (66%) compared to vehicle-treated controls.