17 month-old PFA1-treated female mice show trends towards decreased brain Aβ40 and Aβ42. A. Aβ1-40 levels were measured from DEA-extracted (soluble proteins, left) and FA-extracted (insoluble, middle) brain lysates from vehicle (n = 5) or PFA1-treated (n = 5) 17 month-old female mice. Total Aβ levels were calculated as the sum of soluble and insoluble Aβ levels. There was a trend towards decreased soluble (25%) and insoluble (17%) Aβ1-40 levels in PFA1-treated female mice. B. Aβ1-42 levels were measured from DEA and FA lysates from the same female mice treated with vehicle or PFA1. There was a trend towards decreased soluble (32%) and insoluble (24%) Aβ1-42 levels in PFA1-treated female mice.