Figure 3From: Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytesStimulation with acLDL, polystyrene beads, and LPS induces shifts in proportions of Aβ40 variants. The graph depicts the sum of proportions of the 4 different Aβ40 variants after stimulation with LPS, acLDL and polystyrene beads. Note that this sum decreases upon stimulation but remains almost unaffected by the different stimuli accounting for about 60% of Aβtotal. Nonetheless, strong shifts are visible within single Aβx-40 variants resulting in a stimulus-specific signature. Especially the proportion of the Aβ peptide migrating at spot 6.37-F - presumably a variant of Aβ2-40 (Aβ2-40a) - shows strong stimulus-dependent shifts.Back to article page