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Table 2 Proportions of single Aβ peptide species secreted by non-adherent mononuclear phagocytes stimulated with polystyrene beads, acLDL or LPS (2D-Aβ-WIB, mab 1E8)

From: Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes

    CON
(n = 5)
Polystyrene beads
(n = 5)
acLDL
(n = 4)
LPS
(n = 4)
Polystyrene beads + LPS
(n = 4)
Spot pI Aβ identity proposed % of total Aβ
5.37-A 5.37 1-40 63.9 ± 3.8 30.0 ± 7.0*** 37.5 ± 6.5*** 49.2 ± 9.5* 42.0 ± 12.0**
5.37-B 5.37 1-42 3.7 ± 1.9 2.8 ± 0.8 3.2 ± 0.2 4.0 ± 0.1 3.3 ± 0.2
5.37-C 5.37 1-39 1.8 ± 0.1 4.0 ± 0.8*** 4.9 ± 0.4*** 4.8 ± 0.6*** 4.2 ± 0.9***
5.37-D 5.37 1-38 9.6 ± 1.9 12.4 ± 1.1 13.1 ± 1.3* 13.4 ± 1.5* 11.9 ± 2.5
5.37-E 5.37 1-37 5.7 ± 1.2 7.2 ± 1.2 8.5 ± 1.6 7.3 ± 1.2 6.8 ± 2.3
5.37-F 5.37 1-41 2.9 ± 1.6 2.7 ± 0.6 3.0 ± 0.3 3.7 ± 0.2 2.5 ± 0.7
6.37-A 6.37 2-40 1.7 ± 0,7 6.0 ± 1.1** 4.2 ± 0.6 2.8 ± 1.1 6.4 ± 3.1***
6.37-B 6.37 2-42 0.6 ± 0.4 4.3 ± 1.2*** 3.7 ± 0.8** 2.5 ± 1.2* 3.5 ± 1.5**
6.37-F 6.37 n. i.,
2-40a
8.4 ± 5.3 20.1 ± 5.9** 11.4 ± 1.7 4.4 ± 1.5 10.0 ± 2.3
6.37-G 6.37 n. i. 0.5 ± 0.4 4.7 ± 1.2*** 3.8 ± 0.9*** 2.6 ± 1.2* 3.4 ± 1.6**
5.45-A 5.45 n.i.,
2-40b
1.3 ± 0.9 5.9 ± 1.3** 6.7 ± 0.7*** 5.3 ± 2.0** 6.0 ± 2.9**
  1. Values are expressed as mean ± SD; *P < .05, **P < .01, ***P < .001 compared with CON (one-way ANOVA followed by Dunnett's multiple comparison test)
  2. n. i. - not identified