Figure 2
From: Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptidesi
Neuropeptides modulate microglial Aβ 1-42 phagocytosis. FAM-Aβ1-42 phagocytosis was examined in BV2 cells (A, D, G), N9 cells (B, E, H) and primary rat microglia (C, F, I). Cells were incubated for 15 h with bradykinin (BK) (A-C), endothelin (ET) (D-F) or somatostatin (SST) (G-I) at concentrations of 10-9-10-7 M. Thereafter, 0.5 μM of FAM-labelled Aβ was added and phagocytosis assessed after 4 h. (n = 4 +/- SEM; one-way ANOVA followed by Tukey's post test, * P < 0.05 vs. control, ** P < 0.01 vs. control. *** P < 0.001 vs. control).