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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptidesi

Figure 5

Expression of neprilysin (NEP) and insulin-degrading enzyme (IDE) in BV2 cells. Cells were incubated with bradykinin (BK) (A, B), somatostatin (SST) (C, D) or endothelin (ET) (E, F) at concentrations of 10-7 M each. Then, Aβ1-42 (0.5 μM) was added and the cells incubated for additional 4 h. Western blot analysis was performed using whole cell lysates and antibodies directed against NEP (B, D, F), IDE (A, C, E) and β-actin. Representative gels of three independent experiments (n = 3 +/- SEM; one-way ANOVA followed by Tukey's post test, *P < 0.05).

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