Skip to main content
Figure 1 | Journal of Neuroinflammation

Figure 1

From: Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease

Figure 1

Back-crossed WKY TG rats show the basic features of the WKY strain. Rats of the WKY TG line in the F5 generation demonstrated morphological features of the WKY strain, including elongated skull shape (A) and increased body size (C), compared to SHR rats (B, D). Systolic blood pressure measurements show chronic hypertension in SHR controls and SHR TG rats, and confirm normal blood pressure in WKY controls as well as in the back-crossed WKY TG line (E). The influence of genetic background factor on systolic blood pressure is highly significant (two-way ANOVA, F = 166.85, *** p < 0.0001), but transgenic factor (F = 1.14, p = 0.30) or their interaction (F = 0.2, p = 0.66) does not influence the blood pressure of the rats. Transgene expression (measured as ratio of human misfolded to rat endogenous tau) is almost identical in the brains of SHR TG and WKY TG rats (F).

Back to article page