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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease

Figure 2

Qualitative and quantitative profile of neurofibrillary pathology in two transgenic rat models of human tauopathy. NFTs show similar morphological and immunohistochemical features in both transgenic lines - WKY TG (A, C) and SHR TG (B, D). Neurofibrillary tangles were stained by Gallyas silver staining (A, B, reticular nuclei) and immunolabeled with antibody AT8 recognizing tau phosphorylated at Ser202 and Thr205 (C, D, reticular nuclei). Phosphorylated tau is also distributed in neuronal processes, resulting in axonopathy visible in the white matter (E, F). The number of NFTs was stereologically quantified in brainstem (pons and medulla oblongata) as a region of interest (G). Stereological analysis revealed significantly lower number of NFTs in WKY TG rats compared to SHR TG rats (H, Student's t-test, * p < 0.05). Pre-fixed frozen sections. Scale bars: 50 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094