Skip to main content
Figure 3 | Journal of Neuroinflammation

Figure 3

From: Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease

Figure 3

Qualitative profile of activated microglia in two transgenic rat models of human tauopathy. Microglia in brainstem of WKY TG (A, C, E) as well as SHR TG (B, D, F) rats show increased expression of activation markers. Large number of microglia strongly immunoreactive for CD11b/CD18 (complement 3 receptor) (A, B) demonstrate the involvement of complement system in the tau-induced neuroinflammation. CD4 co-receptor is usually present on T-cells interacting with MHCII-positive antigen presenting cells; in tau-induced neuroinflammation it is increased mainly on microglia/macrophages (C, D). Round-shaped cell parts positive for CD68 (lysosomal membrane glycoprotein) indicate putative phagocytosis (E, F). Post-fixed (A, B, C, D) and pre-fixed (E, F) frozen sections. Scale bars: 50 μm.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094