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Figure 2 | Journal of Neuroinflammation

Figure 2

From: P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus

Figure 2

MPO-positive neutrophil infiltration following SE. (A) Saline-infused animal, (B) BzATP-infused animal, (C) OxATP-infused animal. In saline-infused animals, neutrophils are observed in the perivascular parenchyma of the FPC at 1 day after SE (A1). Two-to- three days after SE, the number of neutrophils is increased in this region (A2-3). Four days after SE, the number of neutrophils is markedly reduced (A4). In BzATP-infused animals, infiltration of neutrophils into the FPC is detected at 12 hr after SE (B1). At 1-3 days after SE, the numbers of neutrophils is increased (B2-3). Four days after SE, the number of neutrophils is markedly reduced (B4). In OxATP-infused animals, neutrophils infiltrate into the FPC at 1 day after SE (C1). Two-to-three days after SE, the number of neutrophils is increased in the FPC (C2-3). Four days after SE, the number of neutrophils is markedly reduced (C4). In PC, massive neutrophil infiltration is detected in the layer III/IV of the saline-infused animals at 1-2 days after SE (A5). BzATP or OxATP infusion did not affect neutrophil infiltration in the PC (A5, B5 and C5). Bar = 50 μm.

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