Figure 8

MIP-2 expression following SE. (A) Saline-infused animal, (B) BzATP-infused animal, (C) OxATP-infused animal. In saline-infused animals, astrocytes show MIP-2 immunoreactivity at 1 day after SE (A1 and D1-3). At 2-3 days after SE, both astrocytes and neurons show MIP-2 immunoreactivity (A2-3). In BzATP-infused animals, MIP-2 immunoreactivity is observed in astrocytes at 12 hr after SE (B1). At 1-2 days after SE, both astrocytes and neurons show MIP-2 immunoreactivity (B2-3). In OxATP-infused animals, MIP-2 immunoreactivity is observed in astrocytes at 1 day after SE (C1). At 2-3 days after SE, both astrocytes and neurons show MIP-2 immunoreactivity (C2-3). Double immunofluorescent study shows that astrocytes contain both MIP-2 (D1-3) and CCR2 (E1-3) immunoreactivities. Bars = 50 μm (panels A, B and C) and 25 μm (panels D and E) μm.