Figure 1

Gf facilitates the detection of inflammatory plaques. Coronal (A, B, D, E) and axial (C) T1- weighted images are depicted 24 h after Gf injection (left column) and immediately after Gd-DTPA injection (right column). Periventricular pathology was better assessable applying Gf (A and B: ovoid). The disruption of the blood-CSF barrier frequently caused leakage of contrast agent into the CSF (A, B, E: arrowhead), initially obscuring periventricular lesions. A parenchymal midbrain lesion is shown exemplary (C: encircled) that was not seen with Gd-DTPA. Visualization of optic neuritis (D and E: square) was markedly improved by Gf, since neighboring intravascular signal prohibited the unambiguous determination on Gd-DTPA-enhanced images (D and E: arrow).