Figure 5

Quantitative comparison of Gf enhancement in circumventricular organs (CVO). Gf enhancement was quantitatively assessed computing the Gf mean intensity ratio of the CVO in T1-weighted images 24 h after Gf application. The comparison between EAE and naïve control animals was performed using two-tailed Mann-Whitney-U tests. Gf enhancement in EAE mice was significantly higher in the choroid plexus (**: P = 0.008), the subfornicular organ (*: P = 0.020) and the area postrema (*: P = 0.016). SFO: subfornicular organ; OVLT: organum vasculosum of the lamina terminalis; ME: median eminence; AP: area postrema.