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Table 4 Gf enhancement differentiates between EAE animals and healthy controls

From: Gadofluorine M-enhanced MRI shows involvement of circumventricular organs in neuroinflammation

 

Choroid plexus

SFO

AP

Area under the ROC curve

0.90

0.81

0.84

Standard error (95% CI)

0.07 (0.77 to 1.03)

0.09 (0.64 to 0.98)

0.08 (0.68 to 1.01)

P value (two-tailed)

0.007

0.018

0.014

Significance

**

*

*

Cutoff MIR

>0.9826

>1.232

>1.189

Sensitivity (95% CI)

89% (65 to 99%)

67% (41 to 87%)

82% (57 to 96%)

Specificity (95% CI)

80% (28 to 100%)

86% (42 to 100%)

83% (36 to 100%)

Likelihood ratio

4.44

4.67

4.94

  1. ROC analysis of the Gf enhancement (mean intensity ratios) in circumventricular organs, differentiating between EAE animals and controls. Exemplary cut-off values and the resulting sensitivity, specificity and likelihood ratio are presented for each region
  2. ROC: receiver operating characteristic; SFO: subfornicular organ; AP: area postrema; *: P value < 0.05; **: P value < 0.01; MIR: mean intensity ratio; CI: confidence interval